Drug interactions
Empagliflozin + Tolazamide
Severity: Moderate
Empagliflozin and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin added to a sulfonylurea increases the likelihood of hypoglycemia. The sulfonylurea dose often needs to be lowered.
What this interaction means in plain words
Empagliflozin and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin belongs to Endocrine; Tolazamide belongs to Endocrine.
Why it happens
Additive glucose lowering from sulfonylurea-stimulated insulin secretion and SGLT2-mediated glucosuria.
What to do
Consider reducing the tolazamide dose when starting empagliflozin and monitor blood glucose closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Empagliflozin and Tolazamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Frequently asked questions
Can I take Empagliflozin with Tolazamide?
MediHelp rates the interaction as moderate. Empagliflozin and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin added to a sulfonylurea increases the likelihood of hypoglycemia. The sulfonylurea dose often needs to be lowered.
How serious is the interaction between Empagliflozin and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the tolazamide dose when starting empagliflozin and monitor blood glucose closely.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
