Drug interactions
Entecavir + Pentamidine
Severity: Moderate
Entecavir and Pentamidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentamidine, especially given systemically, can cause nephrotoxicity. Reduced renal function could raise entecavir exposure, because entecavir is cleared by the kidneys.
What this interaction means in plain words
Entecavir and Pentamidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entecavir belongs to Anti Virals; Pentamidine belongs to Anti Parasitic.
Why it happens
Pentamidine-induced kidney injury may reduce renal clearance of entecavir.
What to do
Monitor serum creatinine and adjust the entecavir dose to creatinine clearance if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Entecavir
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Entecavir with Pentamidine?
MediHelp rates the interaction as moderate. Entecavir and Pentamidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentamidine, especially given systemically, can cause nephrotoxicity. Reduced renal function could raise entecavir exposure, because entecavir is cleared by the kidneys.
How serious is the interaction between Entecavir and Pentamidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and adjust the entecavir dose to creatinine clearance if renal function declines.
What other medicines interact with Entecavir?
MediHelp also lists interactions of Entecavir with, for example, Alogliptin-metformin, Canagliflozin-metformin, Cidofovir. The full list is on the Entecavir page.
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