Drug interactions
Entecavir + Zoledronic acid
Severity: Minor
Entecavir and Zoledronic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zoledronic acid is cleared by the kidney and can impair renal function, and entecavir is eliminated renally by filtration and tubular secretion. Reduced renal function could raise entecavir exposure. The effect is predicted and unlikely to be significant in most patients.
What this interaction means in plain words
Entecavir and Zoledronic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entecavir belongs to Anti Virals; Zoledronic acid belongs to Musculoskeletal.
Why it happens
Possible reduction in renal clearance of entecavir if zoledronic acid causes renal impairment.
What to do
Monitor serum creatinine in patients receiving both drugs and adjust entecavir dose to creatinine clearance if renal function declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zoledronic acid
- Amikacin + Zoledronic acid Moderate
- Bumetanide + Zoledronic acid Moderate
- Dichlorphenamide + Zoledronic acid Moderate
- Ethacrynic acid + Zoledronic acid Moderate
- Foscarnet + Zoledronic acid Moderate
- Gentamicin + Zoledronic acid Moderate
Other interactions of Entecavir
Frequently asked questions
Can I take Entecavir with Zoledronic acid?
MediHelp rates the interaction as minor. Entecavir and Zoledronic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zoledronic acid is cleared by the kidney and can impair renal function, and entecavir is eliminated renally by filtration and tubular secretion. Reduced renal function could raise entecavir exposure. The effect is predicted and unlikely to be significant in most patients.
How serious is the interaction between Entecavir and Zoledronic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine in patients receiving both drugs and adjust entecavir dose to creatinine clearance if renal function declines.
What other medicines interact with Zoledronic acid?
MediHelp also lists interactions of Zoledronic acid with, for example, Amikacin, Bumetanide, Dichlorphenamide. The full list is on the Zoledronic acid page.
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