Drug interactions
Enzalutamide + Ergotamine
Severity: Moderate
Enzalutamide and Ergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and can lower ergotamine exposure. This may reduce headache efficacy and makes the dose-response unpredictable. Erratic exposure, followed by loss of induction after stopping enzalutamide, complicates the use of a drug with a narrow safety margin.
What this interaction means in plain words
Enzalutamide and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Ergotamine belongs to Central Nervous System.
Why it happens
Enzalutamide induces hepatic and intestinal CYP3A4, increasing ergotamine metabolism.
What to do
Consider a non-ergot migraine therapy such as a triptan or a non-pharmacologic approach while the patient is on enzalutamide. Do not escalate ergotamine doses to compensate for lost effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Ergotamine?
MediHelp rates the interaction as moderate. Enzalutamide and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and can lower ergotamine exposure. This may reduce headache efficacy and makes the dose-response unpredictable. Erratic exposure, followed by loss of induction after stopping enzalutamide, complicates the use of a drug with a narrow safety margin.
How serious is the interaction between Enzalutamide and Ergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-ergot migraine therapy such as a triptan or a non-pharmacologic approach while the patient is on enzalutamide. Do not escalate ergotamine doses to compensate for lost effect.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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