Drug interactions
Enzalutamide + Esomeprazole
Severity: Moderate
Enzalutamide and Esomeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide induces CYP3A4 and CYP2C19, which may lower esomeprazole exposure and reduce acid suppression. The effect is usually modest and the drug is not essential to survival, so loss of effect is manageable.
What this interaction means in plain words
Enzalutamide and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Esomeprazole belongs to Gastrointestinal Tract.
Why it happens
Enzalutamide induces CYP2C19 and CYP3A4, increasing esomeprazole metabolism.
What to do
Monitor for reduced control of reflux or ulcer symptoms and increase the esomeprazole dose if needed. Consider an alternative acid suppressant if symptoms persist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Esomeprazole?
MediHelp rates the interaction as moderate. Enzalutamide and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide induces CYP3A4 and CYP2C19, which may lower esomeprazole exposure and reduce acid suppression. The effect is usually modest and the drug is not essential to survival, so loss of effect is manageable.
How serious is the interaction between Enzalutamide and Esomeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced control of reflux or ulcer symptoms and increase the esomeprazole dose if needed. Consider an alternative acid suppressant if symptoms persist.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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