Drug interactions
Enzalutamide + Estradiol
Severity: Moderate
Enzalutamide and Estradiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estradiol is metabolized partly by CYP3A4, and enzalutamide induction may reduce its levels. This could reduce the effect of hormone therapy, causing return of menopausal symptoms or breakthrough bleeding.
What this interaction means in plain words
Enzalutamide and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Estradiol belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4, increasing estradiol clearance.
What to do
Monitor for reduced estrogenic effect and adjust the estradiol dose if needed. Reassess the need for estradiol therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Enzalutamide with Estradiol?
MediHelp rates the interaction as moderate. Enzalutamide and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Estradiol is metabolized partly by CYP3A4, and enzalutamide induction may reduce its levels. This could reduce the effect of hormone therapy, causing return of menopausal symptoms or breakthrough bleeding.
How serious is the interaction between Enzalutamide and Estradiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced estrogenic effect and adjust the estradiol dose if needed. Reassess the need for estradiol therapy.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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