Drug interactions
Enzalutamide + Everolimus
Severity: Major
Enzalutamide and Everolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Everolimus is a CYP3A4 and P-gp substrate, and strong inducers lower its concentrations considerably. This may reduce efficacy in oncology or increase rejection risk in transplant patients.
What this interaction means in plain words
Enzalutamide and Everolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Everolimus belongs to Oncology.
Why it happens
Enzalutamide induces CYP3A4 and P-gp, increasing everolimus clearance.
What to do
Avoid if possible. If necessary, the everolimus dose may be increased per labeling for oncology use, with trough monitoring in transplant patients, and reduced again after the inducer is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Enzalutamide with Everolimus?
MediHelp rates the interaction as major. Enzalutamide and Everolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Everolimus is a CYP3A4 and P-gp substrate, and strong inducers lower its concentrations considerably. This may reduce efficacy in oncology or increase rejection risk in transplant patients.
How serious is the interaction between Enzalutamide and Everolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If necessary, the everolimus dose may be increased per labeling for oncology use, with trough monitoring in transplant patients, and reduced again after the inducer is stopped.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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