Drug interactions
Enzalutamide + Finerenone
Severity: Major
Enzalutamide and Finerenone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Finerenone is cleared mainly by CYP3A4, and strong inducers markedly reduce its exposure. Enzalutamide may therefore diminish its cardiorenal benefit.
What this interaction means in plain words
Enzalutamide and Finerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Finerenone belongs to Cardiovascular.
Why it happens
Enzalutamide induces CYP3A4, increasing finerenone clearance.
What to do
Avoid coadministration as labeling advises against strong CYP3A4 inducers. If unavoidable, monitor potassium and renal function and consider alternatives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Enzalutamide with Finerenone?
MediHelp rates the interaction as major. Enzalutamide and Finerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Finerenone is cleared mainly by CYP3A4, and strong inducers markedly reduce its exposure. Enzalutamide may therefore diminish its cardiorenal benefit.
How serious is the interaction between Enzalutamide and Finerenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration as labeling advises against strong CYP3A4 inducers. If unavoidable, monitor potassium and renal function and consider alternatives.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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