Drug interactions
Enzalutamide + Idelalisib
Severity: Major
Enzalutamide and Idelalisib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and can markedly lower idelalisib exposure, risking loss of antitumor efficacy. Idelalisib is a strong CYP3A inhibitor and may raise enzalutamide and its active metabolite levels, although the net effect on enzalutamide is less well characterized.
What this interaction means in plain words
Enzalutamide and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Idelalisib belongs to Oncology.
Why it happens
Enzalutamide induces CYP3A4 (increasing idelalisib clearance), while idelalisib inhibits CYP3A4 (reducing enzalutamide clearance).
What to do
Avoid the combination; consider an alternative to one of the agents. If unavoidable, monitor for reduced idelalisib response and for enzalutamide adverse effects such as seizures and fatigue.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Enzalutamide with Idelalisib?
MediHelp rates the interaction as major. Enzalutamide and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide is a strong CYP3A4 inducer and can markedly lower idelalisib exposure, risking loss of antitumor efficacy. Idelalisib is a strong CYP3A inhibitor and may raise enzalutamide and its active metabolite levels, although the net effect on enzalutamide is less well characterized.
How serious is the interaction between Enzalutamide and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; consider an alternative to one of the agents. If unavoidable, monitor for reduced idelalisib response and for enzalutamide adverse effects such as seizures and fatigue.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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