Drug interactions
Enzalutamide + Modafinil
Severity: Moderate
Enzalutamide and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and can lower modafinil exposure, potentially reducing its wake-promoting effect. The reduction is predicted from mechanism rather than clearly quantified.
What this interaction means in plain words
Enzalutamide and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Modafinil belongs to Central Nervous System.
Why it happens
Enzalutamide induces CYP3A4, increasing modafinil clearance.
What to do
Monitor clinical response to modafinil and increase the dose if efficacy declines; reassess when enzalutamide is stopped, as the induction wanes slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Modafinil?
MediHelp rates the interaction as moderate. Enzalutamide and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and can lower modafinil exposure, potentially reducing its wake-promoting effect. The reduction is predicted from mechanism rather than clearly quantified.
How serious is the interaction between Enzalutamide and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to modafinil and increase the dose if efficacy declines; reassess when enzalutamide is stopped, as the induction wanes slowly.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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