Drug interactions
Enzalutamide + Nevirapine
Severity: Major
Enzalutamide and Nevirapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and may lower nevirapine concentrations, risking loss of antiretroviral control and resistance. Nevirapine may in turn modestly alter enzalutamide exposure as a CYP3A4/2B6 inducer.
What this interaction means in plain words
Enzalutamide and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Nevirapine belongs to Anti Virals.
Why it happens
Enzalutamide induces CYP3A4 and CYP2B6, increasing nevirapine metabolism.
What to do
Avoid the combination where possible and consider an alternative antiretroviral regimen. If used together, monitor HIV viral load and consider nevirapine plasma level checks.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Nevirapine?
MediHelp rates the interaction as major. Enzalutamide and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide is a strong CYP3A4 inducer and may lower nevirapine concentrations, risking loss of antiretroviral control and resistance. Nevirapine may in turn modestly alter enzalutamide exposure as a CYP3A4/2B6 inducer.
How serious is the interaction between Enzalutamide and Nevirapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and consider an alternative antiretroviral regimen. If used together, monitor HIV viral load and consider nevirapine plasma level checks.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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