Drug interactions
Enzalutamide + Oxycodone
Severity: Moderate
Enzalutamide and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and can substantially lower oxycodone exposure, reducing pain relief. After enzalutamide is stopped, induction fades slowly and oxycodone levels may rise.
What this interaction means in plain words
Enzalutamide and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Oxycodone belongs to Musculoskeletal.
Why it happens
Induction of CYP3A4-mediated oxycodone metabolism by enzalutamide.
What to do
Monitor analgesic response and titrate oxycodone as needed. Watch for toxicity and reduce the dose when enzalutamide is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Oxycodone?
MediHelp rates the interaction as moderate. Enzalutamide and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and can substantially lower oxycodone exposure, reducing pain relief. After enzalutamide is stopped, induction fades slowly and oxycodone levels may rise.
How serious is the interaction between Enzalutamide and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and titrate oxycodone as needed. Watch for toxicity and reduce the dose when enzalutamide is discontinued.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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