Drug interactions
Enzalutamide + Palbociclib
Severity: Major
Enzalutamide and Palbociclib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palbociclib is cleared mainly by CYP3A, and strong inducers markedly reduce its exposure. This may reduce anticancer efficacy.
What this interaction means in plain words
Enzalutamide and Palbociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Palbociclib belongs to Oncology.
Why it happens
Enzalutamide induces CYP3A4, increasing palbociclib clearance.
What to do
Avoid concomitant use and select an alternative to enzalutamide when possible. If it is used, monitor response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Palbociclib
Frequently asked questions
Can I take Enzalutamide with Palbociclib?
MediHelp rates the interaction as major. Enzalutamide and Palbociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Palbociclib is cleared mainly by CYP3A, and strong inducers markedly reduce its exposure. This may reduce anticancer efficacy.
How serious is the interaction between Enzalutamide and Palbociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and select an alternative to enzalutamide when possible. If it is used, monitor response.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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