Drug interactions
Enzalutamide + Pretomanid
Severity: Major
Enzalutamide and Pretomanid: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid is metabolized in part by CYP3A4, and enzalutamide may reduce its levels, risking reduced antimycobacterial efficacy and treatment failure.
What this interaction means in plain words
Enzalutamide and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Pretomanid belongs to Anti Bacterial.
Why it happens
Enzalutamide induces CYP3A4, increasing pretomanid clearance.
What to do
Avoid coadministration; consider an alternative to enzalutamide during tuberculosis therapy. Monitor microbiological response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Pretomanid
Frequently asked questions
Can I take Enzalutamide with Pretomanid?
MediHelp rates the interaction as major. Enzalutamide and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pretomanid is metabolized in part by CYP3A4, and enzalutamide may reduce its levels, risking reduced antimycobacterial efficacy and treatment failure.
How serious is the interaction between Enzalutamide and Pretomanid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration; consider an alternative to enzalutamide during tuberculosis therapy. Monitor microbiological response.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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