Drug interactions
Enzalutamide + Repotrectinib
Severity: Major
Enzalutamide and Repotrectinib: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib is metabolized by CYP3A4, and strong inducers markedly reduce its exposure. Enzalutamide coadministration is likely to cause loss of tumor control.
What this interaction means in plain words
Enzalutamide and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Repotrectinib belongs to Oncology.
Why it happens
Enzalutamide induces CYP3A4, accelerating repotrectinib clearance.
What to do
Avoid concurrent use; labeling advises against strong or moderate CYP3A inducers. Choose an alternative to enzalutamide where feasible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Enzalutamide with Repotrectinib?
MediHelp rates the interaction as major. Enzalutamide and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Repotrectinib is metabolized by CYP3A4, and strong inducers markedly reduce its exposure. Enzalutamide coadministration is likely to cause loss of tumor control.
How serious is the interaction between Enzalutamide and Repotrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; labeling advises against strong or moderate CYP3A inducers. Choose an alternative to enzalutamide where feasible.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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