Drug interactions
Enzalutamide + Rucaparib
Severity: Minor
Enzalutamide and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a moderate CYP3A4 inhibitor and could modestly raise enzalutamide exposure. The clinical impact is likely small because enzalutamide has a wide therapeutic range.
What this interaction means in plain words
Enzalutamide and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enzalutamide belongs to Endocrine; Rucaparib belongs to Oncology.
Why it happens
Rucaparib weakly to moderately inhibits CYP3A4, reducing enzalutamide metabolism.
What to do
No routine dose change is needed. Monitor for enzalutamide adverse effects such as fatigue, hypertension and seizures.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Enzalutamide with Rucaparib?
MediHelp rates the interaction as minor. Enzalutamide and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a moderate CYP3A4 inhibitor and could modestly raise enzalutamide exposure. The clinical impact is likely small because enzalutamide has a wide therapeutic range.
How serious is the interaction between Enzalutamide and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for enzalutamide adverse effects such as fatigue, hypertension and seizures.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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