Drug interactions
Enzalutamide + Stiripentol
Severity: Moderate
Enzalutamide and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol is metabolized by several enzymes including CYP3A4 and CYP2C19, which enzalutamide induces. Lower stiripentol concentrations may reduce seizure control.
What this interaction means in plain words
Enzalutamide and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Stiripentol belongs to Central Nervous System.
Why it happens
Enzalutamide induces CYP3A4 and CYP2C19, increasing stiripentol clearance.
What to do
Monitor seizure frequency and consider increasing stiripentol dose if needed. Consider alternatives to enzalutamide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Enzalutamide with Stiripentol?
MediHelp rates the interaction as moderate. Enzalutamide and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol is metabolized by several enzymes including CYP3A4 and CYP2C19, which enzalutamide induces. Lower stiripentol concentrations may reduce seizure control.
How serious is the interaction between Enzalutamide and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency and consider increasing stiripentol dose if needed. Consider alternatives to enzalutamide.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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