Drug interactions
Ergocalciferol + Metolazone
Severity: Moderate
Ergocalciferol and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone, a thiazide-like diuretic, decreases urinary calcium excretion and may contribute to hypercalcemia when given with vitamin D.
What this interaction means in plain words
Ergocalciferol and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergocalciferol belongs to Musculoskeletal; Metolazone belongs to Cardiovascular.
Why it happens
Metolazone increases renal calcium reabsorption, which adds to vitamin D-enhanced calcium absorption.
What to do
Monitor serum calcium during combined therapy. Reduce the vitamin D dose if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergocalciferol
- Aluminum hydroxide + Ergocalciferol Moderate
- Calcium acetate + Ergocalciferol Moderate
- Calcium carbonate + Ergocalciferol Moderate
- Calcium chloride + Ergocalciferol Moderate
- Calcium citrate + Ergocalciferol Moderate
- Calcium gluconate + Ergocalciferol Moderate
Other interactions of Metolazone
Frequently asked questions
Can I take Ergocalciferol with Metolazone?
MediHelp rates the interaction as moderate. Ergocalciferol and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone, a thiazide-like diuretic, decreases urinary calcium excretion and may contribute to hypercalcemia when given with vitamin D.
How serious is the interaction between Ergocalciferol and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium during combined therapy. Reduce the vitamin D dose if hypercalcemia develops.
What other medicines interact with Ergocalciferol?
MediHelp also lists interactions of Ergocalciferol with, for example, Aluminum hydroxide, Calcium acetate, Calcium carbonate. The full list is on the Ergocalciferol page.
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