Drug interactions
Ertugliflozin + Insulin glargine
Severity: Moderate
Ertugliflozin and Insulin glargine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ertugliflozin used with insulin raises the risk of hypoglycemia. Insulin dose reductions made too aggressively may also predispose to ketoacidosis.
What this interaction means in plain words
Ertugliflozin and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin belongs to Endocrine; Insulin glargine belongs to Endocrine.
Why it happens
Additive glucose lowering from insulin and SGLT2 inhibition with urinary glucose loss.
What to do
Consider a lower insulin dose when starting ertugliflozin and monitor glucose and ketone symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Other interactions of Ertugliflozin
- Chlorpropamide + Ertugliflozin Moderate
- Ertugliflozin + Glibenclamide Moderate
- Ertugliflozin + Gliclazide Moderate
- Ertugliflozin + Glimepiride Moderate
- Ertugliflozin + Glimepiride-pioglitazone Moderate
- Ertugliflozin + Glipizide Moderate
Frequently asked questions
Can I take Ertugliflozin with Insulin glargine?
MediHelp rates the interaction as moderate. Ertugliflozin and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ertugliflozin used with insulin raises the risk of hypoglycemia. Insulin dose reductions made too aggressively may also predispose to ketoacidosis.
How serious is the interaction between Ertugliflozin and Insulin glargine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower insulin dose when starting ertugliflozin and monitor glucose and ketone symptoms.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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