Drug interactions
Ertugliflozin-sitagliptin + Gemifloxacin
Severity: Moderate
Ertugliflozin-sitagliptin and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia, particularly in diabetic patients on glucose-lowering drugs. Disturbed glucose control may occur when gemifloxacin is added to ertugliflozin-sitagliptin. Gemifloxacin carries less dysglycemia risk than some other quinolones but the effect is still recognized.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin-sitagliptin belongs to Endocrine; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones affect pancreatic beta-cell insulin release, producing dysglycemia that adds to antidiabetic effects.
What to do
Monitor blood glucose closely during the antibiotic course and counsel patients on hypoglycemia symptoms. Consider an alternative antibiotic if glucose control becomes unstable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Gemifloxacin?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia, particularly in diabetic patients on glucose-lowering drugs. Disturbed glucose control may occur when gemifloxacin is added to ertugliflozin-sitagliptin. Gemifloxacin carries less dysglycemia risk than some other quinolones but the effect is still recognized.
How serious is the interaction between Ertugliflozin-sitagliptin and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during the antibiotic course and counsel patients on hypoglycemia symptoms. Consider an alternative antibiotic if glucose control becomes unstable.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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