Drug interactions
Ertugliflozin-sitagliptin + Iloperidone
Severity: Moderate
Ertugliflozin-sitagliptin and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics such as iloperidone can raise blood glucose and worsen glycemic control. This may oppose the effect of antidiabetic medicines. Iloperidone has a relatively modest metabolic liability compared with some agents.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin-sitagliptin belongs to Endocrine; Iloperidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism: antipsychotic-related insulin resistance and impaired glucose regulation.
What to do
Monitor fasting glucose and HbA1c at baseline and periodically during therapy. Intensify antidiabetic treatment if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Iloperidone?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics such as iloperidone can raise blood glucose and worsen glycemic control. This may oppose the effect of antidiabetic medicines. Iloperidone has a relatively modest metabolic liability compared with some agents.
How serious is the interaction between Ertugliflozin-sitagliptin and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c at baseline and periodically during therapy. Intensify antidiabetic treatment if control worsens.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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