Drug interactions
Ertugliflozin-sitagliptin + Lasmiditan
Severity: Minor
Ertugliflozin-sitagliptin and Lasmiditan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-glycoprotein in vitro and may increase levels of P-gp substrates such as sitagliptin. Sitagliptin has a wide therapeutic index, so clinical significance is expected to be small.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ertugliflozin-sitagliptin belongs to Endocrine; Lasmiditan belongs to Central Nervous System.
Why it happens
Lasmiditan inhibits P-gp efflux, potentially increasing sitagliptin exposure.
What to do
No routine adjustment is needed; monitor glycemic control and for sitagliptin adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ertugliflozin-sitagliptin and Lasmiditan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ertugliflozin-sitagliptin
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Lasmiditan?
MediHelp rates the interaction as minor. Ertugliflozin-sitagliptin and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits P-glycoprotein in vitro and may increase levels of P-gp substrates such as sitagliptin. Sitagliptin has a wide therapeutic index, so clinical significance is expected to be small.
How serious is the interaction between Ertugliflozin-sitagliptin and Lasmiditan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor glycemic control and for sitagliptin adverse effects.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
