Drug interactions
Ertugliflozin-sitagliptin + Liraglutide
Severity: Moderate
Ertugliflozin-sitagliptin and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liraglutide and sitagliptin both act on the incretin system, so combining them offers little added benefit, and with ertugliflozin the glucose-lowering effects are additive. Hypoglycemia is uncommon but can occur, especially with sulfonylureas or insulin.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin-sitagliptin belongs to Endocrine; Liraglutide belongs to Endocrine.
Why it happens
Duplicate incretin pathway enhancement (GLP-1 receptor agonism plus DPP-4 inhibition) with additive SGLT2-mediated glucose lowering.
What to do
Avoid combining a GLP-1 agonist with a DPP-4 inhibitor where possible, and consider stopping the sitagliptin component. If used, monitor glucose and review other hypoglycemic agents.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ertugliflozin-sitagliptin and Liraglutide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ertugliflozin-sitagliptin
Other interactions of Liraglutide
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Liraglutide?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liraglutide and sitagliptin both act on the incretin system, so combining them offers little added benefit, and with ertugliflozin the glucose-lowering effects are additive. Hypoglycemia is uncommon but can occur, especially with sulfonylureas or insulin.
How serious is the interaction between Ertugliflozin-sitagliptin and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining a GLP-1 agonist with a DPP-4 inhibitor where possible, and consider stopping the sitagliptin component. If used, monitor glucose and review other hypoglycemic agents.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
