Drug interactions
Ertugliflozin-sitagliptin + Lurasidone
Severity: Minor
Ertugliflozin-sitagliptin and Lurasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone can alter glucose metabolism and may raise blood glucose, opposing the effect of antidiabetic therapy. The metabolic effect of lurasidone is generally smaller than that of some other atypical antipsychotics.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ertugliflozin-sitagliptin belongs to Endocrine; Lurasidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism: antipsychotic-related insulin resistance and impaired glucose regulation oppose antidiabetic action.
What to do
Monitor fasting glucose and HbA1c when starting lurasidone and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Lurasidone?
MediHelp rates the interaction as minor. Ertugliflozin-sitagliptin and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lurasidone can alter glucose metabolism and may raise blood glucose, opposing the effect of antidiabetic therapy. The metabolic effect of lurasidone is generally smaller than that of some other atypical antipsychotics.
How serious is the interaction between Ertugliflozin-sitagliptin and Lurasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c when starting lurasidone and adjust antidiabetic therapy if control worsens.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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