Drug interactions
Erythromycin lactobionate + Ivermectin
Severity: Minor
Erythromycin lactobionate and Ivermectin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits P-glycoprotein and CYP3A4, which may raise systemic ivermectin exposure. Ivermectin has a wide safety margin, so the clinical effect is usually modest, but adverse effects such as dizziness or neurotoxicity are theoretically more likely.
What this interaction means in plain words
Erythromycin lactobionate and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erythromycin lactobionate belongs to Anti Bacterial; Ivermectin belongs to Anti Parasitic.
Why it happens
Erythromycin inhibits intestinal and blood-brain barrier P-glycoprotein efflux and CYP3A4 metabolism of ivermectin.
What to do
No routine dose change is needed. Watch for increased adverse effects such as dizziness, tremor or confusion, especially with repeated or high-dose ivermectin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Lasmiditan Moderate
- Ivermectin + Quinidine Moderate
- Ivermectin + Rifampin Moderate
- Ivermectin + Sotorasib Moderate
- Ivermectin + Tepotinib Moderate
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Ivermectin?
MediHelp rates the interaction as minor. Erythromycin lactobionate and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin inhibits P-glycoprotein and CYP3A4, which may raise systemic ivermectin exposure. Ivermectin has a wide safety margin, so the clinical effect is usually modest, but adverse effects such as dizziness or neurotoxicity are theoretically more likely.
How serious is the interaction between Erythromycin lactobionate and Ivermectin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for increased adverse effects such as dizziness, tremor or confusion, especially with repeated or high-dose ivermectin.
What other medicines interact with Ivermectin?
MediHelp also lists interactions of Ivermectin with, for example, Erdafitinib, Lasmiditan, Quinidine. The full list is on the Ivermectin page.
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