Drug interactions
Eslicarbazepine + Rolapitant
Severity: Moderate
Eslicarbazepine and Rolapitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a CYP3A4 inducer and may reduce rolapitant concentrations with prolonged use. The induction is weaker than that of carbamazepine but could reduce antiemetic efficacy.
What this interaction means in plain words
Eslicarbazepine and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Eslicarbazepine induces CYP3A4, increasing rolapitant metabolism.
What to do
Consider an alternative antiemetic not dependent on rolapitant. If combined, monitor for inadequate emesis control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Rolapitant?
MediHelp rates the interaction as moderate. Eslicarbazepine and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine is a CYP3A4 inducer and may reduce rolapitant concentrations with prolonged use. The induction is weaker than that of carbamazepine but could reduce antiemetic efficacy.
How serious is the interaction between Eslicarbazepine and Rolapitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antiemetic not dependent on rolapitant. If combined, monitor for inadequate emesis control.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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