Drug interactions
Esomeprazole + Liothyronine
Severity: Minor
Esomeprazole and Liothyronine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reduced gastric acidity from esomeprazole may lower the absorption of oral thyroid hormone preparations, though data on liothyronine specifically are limited and inconsistent. A change in thyroid function tests could occur in some patients.
What this interaction means in plain words
Esomeprazole and Liothyronine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esomeprazole belongs to Gastrointestinal Tract; Liothyronine belongs to Endocrine.
Why it happens
Higher gastric pH may impair dissolution and absorption of oral thyroid hormone; the effect is not firmly established for liothyronine.
What to do
Check TSH and free T3/T4 several weeks after starting or stopping esomeprazole and adjust the liothyronine dose if thyroid function shifts.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
Frequently asked questions
Can I take Esomeprazole with Liothyronine?
MediHelp rates the interaction as minor. Esomeprazole and Liothyronine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Reduced gastric acidity from esomeprazole may lower the absorption of oral thyroid hormone preparations, though data on liothyronine specifically are limited and inconsistent. A change in thyroid function tests could occur in some patients.
How serious is the interaction between Esomeprazole and Liothyronine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check TSH and free T3/T4 several weeks after starting or stopping esomeprazole and adjust the liothyronine dose if thyroid function shifts.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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