Drug interactions
Esomeprazole + Posaconazole
Severity: Moderate
Esomeprazole and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Higher gastric pH reduces absorption of posaconazole oral suspension, which depends on acidity, and may lower antifungal exposure. Delayed-release tablets are much less affected. Reduced exposure could compromise prophylaxis or treatment of invasive fungal infection.
What this interaction means in plain words
Esomeprazole and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esomeprazole belongs to Gastrointestinal Tract; Posaconazole belongs to Anti Fungals.
Why it happens
Elevated gastric pH decreases dissolution and absorption of posaconazole suspension.
What to do
Prefer the delayed-release tablet or IV formulation when acid suppression is needed, and avoid the suspension with a PPI where possible. Consider posaconazole trough monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Esomeprazole with Posaconazole?
MediHelp rates the interaction as moderate. Esomeprazole and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Higher gastric pH reduces absorption of posaconazole oral suspension, which depends on acidity, and may lower antifungal exposure. Delayed-release tablets are much less affected. Reduced exposure could compromise prophylaxis or treatment of invasive fungal infection.
How serious is the interaction between Esomeprazole and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer the delayed-release tablet or IV formulation when acid suppression is needed, and avoid the suspension with a PPI where possible. Consider posaconazole trough monitoring.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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