Drug interactions
Esomeprazole + Tucatinib
Severity: Minor
Esomeprazole and Tucatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and may raise esomeprazole exposure. Esomeprazole is mostly cleared by CYP2C19 and has a wide margin of safety, so the effect is usually modest.
What this interaction means in plain words
Esomeprazole and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esomeprazole belongs to Gastrointestinal Tract; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, a secondary pathway of esomeprazole metabolism.
What to do
No routine dose change is needed. Watch for esomeprazole adverse effects such as headache and gastrointestinal upset.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Esomeprazole with Tucatinib?
MediHelp rates the interaction as minor. Esomeprazole and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tucatinib inhibits CYP3A4 and may raise esomeprazole exposure. Esomeprazole is mostly cleared by CYP2C19 and has a wide margin of safety, so the effect is usually modest.
How serious is the interaction between Esomeprazole and Tucatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for esomeprazole adverse effects such as headache and gastrointestinal upset.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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