Drug interactions
Estradiol + Teriflunomide
Severity: Minor
Estradiol and Teriflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide increases exposure to ethinylestradiol, and estradiol is also partly metabolized by CYP1A2 so the induction note is not consistent with the known effect. The expected effect on estradiol is uncertain and probably of little clinical relevance.
What this interaction means in plain words
Estradiol and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Estradiol belongs to Endocrine; Teriflunomide belongs to Central Nervous System.
Why it happens
Teriflunomide is a weak CYP1A2 inducer, and estradiol is only partly CYP1A2-dependent; the net effect is not well established.
What to do
No action beyond awareness; monitor for changes in estrogen effect or breakthrough bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Teriflunomide
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Teriflunomide?
MediHelp rates the interaction as minor. Estradiol and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide increases exposure to ethinylestradiol, and estradiol is also partly metabolized by CYP1A2 so the induction note is not consistent with the known effect. The expected effect on estradiol is uncertain and probably of little clinical relevance.
How serious is the interaction between Estradiol and Teriflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action beyond awareness; monitor for changes in estrogen effect or breakthrough bleeding.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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