Drug interactions
Estradiol + Tucatinib
Severity: Moderate
Estradiol and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and may raise estradiol exposure. Increased estrogenic effects are possible, which matters for patients with hormone-sensitive disease.
What this interaction means in plain words
Estradiol and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Estradiol belongs to Endocrine; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, reducing estradiol clearance.
What to do
Monitor for estrogen excess and reduce the estradiol dose if needed. Review the indication for estrogen in breast cancer patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Estradiol with Tucatinib?
MediHelp rates the interaction as moderate. Estradiol and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits CYP3A4 and may raise estradiol exposure. Increased estrogenic effects are possible, which matters for patients with hormone-sensitive disease.
How serious is the interaction between Estradiol and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogen excess and reduce the estradiol dose if needed. Review the indication for estrogen in breast cancer patients.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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