Drug interactions
Etanercept + Lomustine
Severity: Moderate
Etanercept and Lomustine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomustine causes delayed and prolonged myelosuppression, and etanercept increases the risk of serious infections. Together the risk of infection may be higher.
What this interaction means in plain words
Etanercept and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etanercept belongs to Musculoskeletal; Lomustine belongs to Oncology.
Why it happens
Additive immunosuppression and myelosuppression.
What to do
Monitor complete blood counts for several weeks after lomustine doses and watch for infection. Consider holding etanercept during neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etanercept
- Bcg vaccine live + Etanercept Contraindicated
- Etanercept + Golimumab Contraindicated
- Etanercept + Measles mumps and rubella vaccine Contraindicated
- Etanercept + Measles mumps and rubella vaccine live Contraindicated
- Etanercept + Measles mumps rubella and varicella vaccine live Contraindicated
- Etanercept + Measles vaccine Contraindicated
Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Etanercept with Lomustine?
MediHelp rates the interaction as moderate. Etanercept and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomustine causes delayed and prolonged myelosuppression, and etanercept increases the risk of serious infections. Together the risk of infection may be higher.
How serious is the interaction between Etanercept and Lomustine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts for several weeks after lomustine doses and watch for infection. Consider holding etanercept during neutropenia.
What other medicines interact with Etanercept?
MediHelp also lists interactions of Etanercept with, for example, Bcg vaccine live, Golimumab, Measles mumps and rubella vaccine. The full list is on the Etanercept page.
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