Drug interactions
Everolimus + Glofitamab
Severity: Moderate
Everolimus and Glofitamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glofitamab induces cytokine release that can transiently suppress CYP450 activity and raise concentrations of CYP3A4 substrates such as everolimus. The risk is highest after initial doses and during cytokine release syndrome.
What this interaction means in plain words
Everolimus and Glofitamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Everolimus belongs to Oncology; Glofitamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP3A4 reduces everolimus metabolism.
What to do
Monitor for everolimus toxicity and check trough levels in the days after glofitamab dosing, especially at treatment initiation. Reduce the everolimus dose if concentrations or adverse effects increase.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Glofitamab
- Ergotamine + Glofitamab Major
- Glofitamab + Pimozide Major
- Bendamustine + Glofitamab Moderate
- Carbamazepine + Glofitamab Moderate
- Clomipramine + Glofitamab Moderate
- Clozapine + Glofitamab Moderate
Frequently asked questions
Can I take Everolimus with Glofitamab?
MediHelp rates the interaction as moderate. Everolimus and Glofitamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glofitamab induces cytokine release that can transiently suppress CYP450 activity and raise concentrations of CYP3A4 substrates such as everolimus. The risk is highest after initial doses and during cytokine release syndrome.
How serious is the interaction between Everolimus and Glofitamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for everolimus toxicity and check trough levels in the days after glofitamab dosing, especially at treatment initiation. Reduce the everolimus dose if concentrations or adverse effects increase.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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