Drug interactions
Everolimus + Pacritinib
Severity: Moderate
Everolimus and Pacritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib is a CYP3A4 substrate with some inhibitory activity and may modestly raise everolimus levels, potentially increasing everolimus adverse effects. The data on magnitude are limited.
What this interaction means in plain words
Everolimus and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Everolimus belongs to Oncology; Pacritinib belongs to Oncology.
Why it happens
Pacritinib may inhibit CYP3A4 and P-gp, reducing everolimus clearance, though the mechanism is not firmly established.
What to do
Monitor everolimus trough levels and watch for toxicity such as stomatitis, infection and cytopenias. Reduce the everolimus dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Everolimus with Pacritinib?
MediHelp rates the interaction as moderate. Everolimus and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pacritinib is a CYP3A4 substrate with some inhibitory activity and may modestly raise everolimus levels, potentially increasing everolimus adverse effects. The data on magnitude are limited.
How serious is the interaction between Everolimus and Pacritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough levels and watch for toxicity such as stomatitis, infection and cytopenias. Reduce the everolimus dose if levels rise.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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