Drug interactions
Everolimus + Teclistamab
Severity: Moderate
Everolimus and Teclistamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teclistamab induces cytokine release that can transiently suppress CYP450 enzymes, potentially raising everolimus concentrations. Higher exposure increases the risk of everolimus adverse effects such as mucositis, infection and pneumonitis.
What this interaction means in plain words
Everolimus and Teclistamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Everolimus belongs to Oncology; Teclistamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP3A4 activity reduces everolimus clearance during cytokine release syndrome.
What to do
Monitor for everolimus toxicity during teclistamab step-up dosing and any CRS episode. Check everolimus trough levels and lower the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Teclistamab
- Pimozide + Teclistamab Major
- Carbamazepine + Teclistamab Moderate
- Colchicine + Teclistamab Moderate
- Cyclosporin + Teclistamab Moderate
- Divalproex + Teclistamab Moderate
- Ergotamine + Teclistamab Moderate
Frequently asked questions
Can I take Everolimus with Teclistamab?
MediHelp rates the interaction as moderate. Everolimus and Teclistamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teclistamab induces cytokine release that can transiently suppress CYP450 enzymes, potentially raising everolimus concentrations. Higher exposure increases the risk of everolimus adverse effects such as mucositis, infection and pneumonitis.
How serious is the interaction between Everolimus and Teclistamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for everolimus toxicity during teclistamab step-up dosing and any CRS episode. Check everolimus trough levels and lower the dose as needed.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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