Drug interactions
Ezetimibe + Trofinetide
Severity: Minor
Ezetimibe and Trofinetide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide inhibits OATP1B1/1B3 in vitro and may raise ezetimibe concentrations. The clinical impact is likely small.
What this interaction means in plain words
Ezetimibe and Trofinetide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ezetimibe belongs to Cardiovascular; Trofinetide belongs to Central Nervous System.
Why it happens
Inhibition of OATP-mediated hepatic uptake of ezetimibe.
What to do
No dose adjustment is needed. Monitor for adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ezetimibe
- Apalutamide + Ezetimibe Moderate
- Cholestyramine + Ezetimibe Moderate
- Cyclosporin + Ezetimibe Moderate
- Ezetimibe + Gemfibrozil Moderate
- Ezetimibe + Glecaprevir / pibrentasvir Moderate
- Ezetimibe + Letermovir Moderate
Other interactions of Trofinetide
Frequently asked questions
Can I take Ezetimibe with Trofinetide?
MediHelp rates the interaction as minor. Ezetimibe and Trofinetide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trofinetide inhibits OATP1B1/1B3 in vitro and may raise ezetimibe concentrations. The clinical impact is likely small.
How serious is the interaction between Ezetimibe and Trofinetide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for adverse effects.
What other medicines interact with Ezetimibe?
MediHelp also lists interactions of Ezetimibe with, for example, Apalutamide, Cholestyramine, Cyclosporin. The full list is on the Ezetimibe page.
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