Drug interactions
Fedratinib + Fenofibric acid
Severity: Minor
Fedratinib and Fenofibric acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4, but fenofibric acid is cleared mainly by glucuronidation, so a clinically important rise in exposure is unlikely.
What this interaction means in plain words
Fedratinib and Fenofibric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fedratinib belongs to Oncology; Fenofibric acid belongs to Cardiovascular.
Why it happens
Theoretical CYP3A4 inhibition by fedratinib with limited relevance to fenofibric acid clearance.
What to do
No dose adjustment is needed. Monitor for adverse effects as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenofibric acid
- Atorvastatin + Fenofibric acid Moderate
- Chlorpropamide + Fenofibric acid Moderate
- Cholestyramine + Fenofibric acid Moderate
- Cholic acid + Fenofibric acid Moderate
- Colchicine + Fenofibric acid Moderate
- Colestipol + Fenofibric acid Moderate
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Fenofibric acid?
MediHelp rates the interaction as minor. Fedratinib and Fenofibric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fedratinib inhibits CYP3A4, but fenofibric acid is cleared mainly by glucuronidation, so a clinically important rise in exposure is unlikely.
How serious is the interaction between Fedratinib and Fenofibric acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for adverse effects as usual.
What other medicines interact with Fenofibric acid?
MediHelp also lists interactions of Fenofibric acid with, for example, Atorvastatin, Chlorpropamide, Cholestyramine. The full list is on the Fenofibric acid page.
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