Drug interactions
Fedratinib + Medroxyprogesterone
Severity: Minor
Fedratinib and Medroxyprogesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and may raise exposure to medroxyprogesterone, which is partly cleared by CYP3A4. Increased progestogenic effects or adverse reactions are possible, though the clinical impact is not well characterized.
What this interaction means in plain words
Fedratinib and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fedratinib belongs to Oncology; Medroxyprogesterone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated metabolism of medroxyprogesterone by fedratinib.
What to do
No routine dose change is needed; watch for progestogenic adverse effects such as bleeding changes, fluid retention or mood changes. Review the need for the progestin if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Medroxyprogesterone
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Medroxyprogesterone?
MediHelp rates the interaction as minor. Fedratinib and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fedratinib is a moderate CYP3A4 inhibitor and may raise exposure to medroxyprogesterone, which is partly cleared by CYP3A4. Increased progestogenic effects or adverse reactions are possible, though the clinical impact is not well characterized.
How serious is the interaction between Fedratinib and Medroxyprogesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for progestogenic adverse effects such as bleeding changes, fluid retention or mood changes. Review the need for the progestin if adverse effects emerge.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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