Drug interactions
Fedratinib + Montelukast
Severity: Minor
Fedratinib and Montelukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4, CYP2C19 and CYP2D6, but montelukast depends mainly on CYP2C8. Any increase in montelukast levels is expected to be small and montelukast has a wide safety margin.
What this interaction means in plain words
Fedratinib and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fedratinib belongs to Oncology; Montelukast belongs to Respiratory.
Why it happens
Fedratinib inhibition of CYP3A4 may slightly reduce a minor montelukast clearance route.
What to do
No dose adjustment is needed. Monitor for montelukast adverse effects such as headache or mood changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Montelukast?
MediHelp rates the interaction as minor. Fedratinib and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fedratinib inhibits CYP3A4, CYP2C19 and CYP2D6, but montelukast depends mainly on CYP2C8. Any increase in montelukast levels is expected to be small and montelukast has a wide safety margin.
How serious is the interaction between Fedratinib and Montelukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for montelukast adverse effects such as headache or mood changes.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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