Drug interactions
Fedratinib + Progesterone
Severity: Minor
Fedratinib and Progesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is metabolized by CYP3A4 and CYP2C19. Progesterone is not a recognized strong inhibitor of these enzymes, so a meaningful interaction is unlikely.
What this interaction means in plain words
Fedratinib and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fedratinib belongs to Oncology; Progesterone belongs to Endocrine.
Why it happens
Weak, theoretical CYP3A4/CYP2C19 inhibition by progesterone.
What to do
No dose adjustment is needed. Monitor for fedratinib adverse effects as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Progesterone
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Progesterone?
MediHelp rates the interaction as minor. Fedratinib and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fedratinib is metabolized by CYP3A4 and CYP2C19. Progesterone is not a recognized strong inhibitor of these enzymes, so a meaningful interaction is unlikely.
How serious is the interaction between Fedratinib and Progesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for fedratinib adverse effects as usual.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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