Drug interactions
Fedratinib + Ticlopidine
Severity: Moderate
Fedratinib and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4, CYP2C19 and CYP2D6 and could raise ticlopidine levels, increasing the risk of adverse effects such as neutropenia. Ticlopidine also inhibits CYP2C19 and CYP2D6, which may raise fedratinib exposure to a small degree.
What this interaction means in plain words
Fedratinib and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Ticlopidine belongs to Cardiovascular.
Why it happens
Fedratinib inhibition of CYP3A4 and CYP2C19 reduces ticlopidine clearance; ticlopidine may modestly inhibit fedratinib metabolism.
What to do
Monitor complete blood counts closely and watch for bleeding or infection; adjust therapy if cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticlopidine
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Ticlopidine?
MediHelp rates the interaction as moderate. Fedratinib and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP3A4, CYP2C19 and CYP2D6 and could raise ticlopidine levels, increasing the risk of adverse effects such as neutropenia. Ticlopidine also inhibits CYP2C19 and CYP2D6, which may raise fedratinib exposure to a small degree.
How serious is the interaction between Fedratinib and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely and watch for bleeding or infection; adjust therapy if cytopenias develop.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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