Drug interactions
Felbamate + Itraconazole
Severity: Moderate
Felbamate and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate is partly metabolized by CYP3A4 and CYP2E1, so a rise in its levels from itraconazole is plausible but the effect is not well characterized. Felbamate has serious toxicity (aplastic anemia, hepatic failure), so any increase is of concern.
What this interaction means in plain words
Felbamate and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felbamate belongs to Central Nervous System; Itraconazole belongs to Anti Fungals.
Why it happens
Possible reduction in felbamate metabolism through CYP3A4 inhibition; the clinical magnitude is not established.
What to do
Monitor for felbamate adverse effects and CBC and liver tests, and adjust the dose if toxicity appears. Consider an alternative antifungal if felbamate levels are hard to control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Felbamate with Itraconazole?
MediHelp rates the interaction as moderate. Felbamate and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felbamate is partly metabolized by CYP3A4 and CYP2E1, so a rise in its levels from itraconazole is plausible but the effect is not well characterized. Felbamate has serious toxicity (aplastic anemia, hepatic failure), so any increase is of concern.
How serious is the interaction between Felbamate and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for felbamate adverse effects and CBC and liver tests, and adjust the dose if toxicity appears. Consider an alternative antifungal if felbamate levels are hard to control.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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