Drug interactions
Felbamate + Losartan
Severity: Minor
Felbamate and Losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate inhibits CYP2C19 and may affect CYP2C9, potentially reducing conversion of losartan to its more potent active metabolite. The clinical significance is not established, and antihypertensive effect could be slightly changed.
What this interaction means in plain words
Felbamate and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Felbamate belongs to Central Nervous System; Losartan belongs to Cardiovascular.
Why it happens
Possible inhibition of CYP2C9-mediated conversion of losartan to E-3174.
What to do
Monitor blood pressure after starting or stopping felbamate and adjust losartan dose to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Felbamate with Losartan?
MediHelp rates the interaction as minor. Felbamate and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Felbamate inhibits CYP2C19 and may affect CYP2C9, potentially reducing conversion of losartan to its more potent active metabolite. The clinical significance is not established, and antihypertensive effect could be slightly changed.
How serious is the interaction between Felbamate and Losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping felbamate and adjust losartan dose to response.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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