Drug interactions
Felbamate + Lurasidone
Severity: Moderate
Felbamate and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, dizziness and somnolence, so combined use may add to CNS depression. Felbamate may also induce CYP3A4, which could modestly lower lurasidone exposure.
What this interaction means in plain words
Felbamate and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felbamate belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible weak CYP3A4 induction by felbamate.
What to do
Monitor for sedation and for loss of antipsychotic effect, adjusting the lurasidone dose to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Felbamate with Lurasidone?
MediHelp rates the interaction as moderate. Felbamate and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, dizziness and somnolence, so combined use may add to CNS depression. Felbamate may also induce CYP3A4, which could modestly lower lurasidone exposure.
How serious is the interaction between Felbamate and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and for loss of antipsychotic effect, adjusting the lurasidone dose to response.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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