Drug interactions
Felbamate + Mefloquine
Severity: Moderate
Felbamate and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate is not a recognized QT-prolonging drug, so any additive cardiac effect with mefloquine is not well supported. The main concern is that both drugs can cause neuropsychiatric effects, and mefloquine can lower the seizure threshold and may reduce antiepileptic control.
What this interaction means in plain words
Felbamate and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felbamate belongs to Central Nervous System; Mefloquine belongs to Anti Parasitic.
Why it happens
Pharmacodynamic opposition: mefloquine is proconvulsant and may counteract felbamate's anticonvulsant effect; no established pharmacokinetic mechanism.
What to do
Use an alternative antimalarial in patients with epilepsy where possible. If mefloquine is used, monitor seizure control and neuropsychiatric symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Felbamate with Mefloquine?
MediHelp rates the interaction as moderate. Felbamate and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felbamate is not a recognized QT-prolonging drug, so any additive cardiac effect with mefloquine is not well supported. The main concern is that both drugs can cause neuropsychiatric effects, and mefloquine can lower the seizure threshold and may reduce antiepileptic control.
How serious is the interaction between Felbamate and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antimalarial in patients with epilepsy where possible. If mefloquine is used, monitor seizure control and neuropsychiatric symptoms.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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