Drug interactions
Felbamate + Midazolam
Severity: Moderate
Felbamate and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate can cause somnolence and, together with midazolam, may increase sedation and respiratory depression. Felbamate also affects CYP enzymes, so midazolam exposure could change.
What this interaction means in plain words
Felbamate and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felbamate belongs to Central Nervous System; Midazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression, plus felbamate's modulation of CYP3A4 and CYP2C19 activity.
What to do
Titrate midazolam carefully and monitor sedation and oxygen saturation. Adjust the dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Felbamate with Midazolam?
MediHelp rates the interaction as moderate. Felbamate and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felbamate can cause somnolence and, together with midazolam, may increase sedation and respiratory depression. Felbamate also affects CYP enzymes, so midazolam exposure could change.
How serious is the interaction between Felbamate and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate midazolam carefully and monitor sedation and oxygen saturation. Adjust the dose according to response.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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