Drug interactions
Felbamate + Piroxicam
Severity: Minor
Felbamate and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate can inhibit certain CYP enzymes including CYP2C19 and may affect CYP2C9 substrates, so piroxicam exposure could rise. The clinical significance is uncertain and probably small.
What this interaction means in plain words
Felbamate and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Felbamate belongs to Central Nervous System; Piroxicam belongs to Musculoskeletal.
Why it happens
Possible felbamate-mediated inhibition of CYP2C9 metabolism of piroxicam; not firmly established.
What to do
No routine dose change is needed; monitor for NSAID adverse effects such as dyspepsia, edema or reduced renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Felbamate with Piroxicam?
MediHelp rates the interaction as minor. Felbamate and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Felbamate can inhibit certain CYP enzymes including CYP2C19 and may affect CYP2C9 substrates, so piroxicam exposure could rise. The clinical significance is uncertain and probably small.
How serious is the interaction between Felbamate and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for NSAID adverse effects such as dyspepsia, edema or reduced renal function.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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