Drug interactions
Felbamate + Ribociclib
Severity: Moderate
Felbamate and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate is partly metabolized by CYP3A4 and CYP2E1. Ribociclib may moderately increase its exposure, which can worsen felbamate adverse effects. Felbamate itself is a CYP3A4 inducer, which could also reduce ribociclib levels.
What this interaction means in plain words
Felbamate and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felbamate belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing felbamate clearance, while felbamate may induce CYP3A4.
What to do
Monitor for felbamate adverse effects and blood counts. Watch for reduced ribociclib efficacy and consider alternative antiepileptics.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Felbamate with Ribociclib?
MediHelp rates the interaction as moderate. Felbamate and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felbamate is partly metabolized by CYP3A4 and CYP2E1. Ribociclib may moderately increase its exposure, which can worsen felbamate adverse effects. Felbamate itself is a CYP3A4 inducer, which could also reduce ribociclib levels.
How serious is the interaction between Felbamate and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for felbamate adverse effects and blood counts. Watch for reduced ribociclib efficacy and consider alternative antiepileptics.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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