Drug interactions
Felbamate + Voriconazole
Severity: Moderate
Felbamate and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate is partly metabolized by CYP3A4 and CYP2E1, and voriconazole may modestly raise its levels. Felbamate may also affect CYP2C19 and thereby voriconazole exposure. Clinical significance is uncertain but felbamate toxicity is serious.
What this interaction means in plain words
Felbamate and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felbamate belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4 and CYP2C19 metabolism of felbamate; felbamate has mixed inhibiting and inducing effects on CYP enzymes.
What to do
Monitor for felbamate adverse effects such as insomnia, nausea and cytopenias, and check voriconazole levels if response is uncertain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Felbamate with Voriconazole?
MediHelp rates the interaction as moderate. Felbamate and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felbamate is partly metabolized by CYP3A4 and CYP2E1, and voriconazole may modestly raise its levels. Felbamate may also affect CYP2C19 and thereby voriconazole exposure. Clinical significance is uncertain but felbamate toxicity is serious.
How serious is the interaction between Felbamate and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for felbamate adverse effects such as insomnia, nausea and cytopenias, and check voriconazole levels if response is uncertain.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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