Drug interactions
Fenfluramine + Prochlorperazine
Severity: Moderate
Fenfluramine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine is used for seizures in Dravet and Lennox-Gastaut syndromes. Prochlorperazine can lower the seizure threshold and both agents can cause CNS effects, so seizure control may be compromised.
What this interaction means in plain words
Fenfluramine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenfluramine belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic opposition (seizure threshold lowering by phenothiazines) and overlapping CNS effects; no direct pharmacokinetic interaction is established.
What to do
Monitor seizure frequency and sedation, and avoid prochlorperazine where an alternative antiemetic is suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fenfluramine and Prochlorperazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Prochlorperazine?
MediHelp rates the interaction as moderate. Fenfluramine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine is used for seizures in Dravet and Lennox-Gastaut syndromes. Prochlorperazine can lower the seizure threshold and both agents can cause CNS effects, so seizure control may be compromised.
How serious is the interaction between Fenfluramine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency and sedation, and avoid prochlorperazine where an alternative antiemetic is suitable.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
